Research on three-dimensional ordered porous carbon-based materials prepared from Acanthopanax senticosus traditional Chinese medicine residues and their drug loading performance
10.16438/j.0513-4870.2024-0286
- VernacularTitle:基于刺五加中药渣制备的三维有序多孔炭材料及其载药性能研究
- Author:
De-sheng WANG
;
Jia-xin FAN
;
Ri-qing CHENG
;
Shi-kui WU
;
Lai-bing WANG
;
Jia-hao SHI
;
Ting-ting CHEN
;
Qin-fang HE
;
Chang-jin XU
;
Hui-qing GUO
- Publication Type:Research Article
- Keywords:
Chinese medicine residue;
italic>Acanthopanax senticosus;
three-dimensional ordered porous carbon material;
rug loading performance;
rug release performance
- From:
Acta Pharmaceutica Sinica
2024;59(10):2857-2863
- CountryChina
- Language:Chinese
-
Abstract:
Three-dimensional ordered porous carbon materials exhibit potential application prospects as excellent drug supports in drug delivery systems due to their high specific surface area, tunable pore structure, and excellent biocompatibility. In this study, three-dimensional ordered porous carbon materials were prepared using Acanthopanax senticosus herbal residues as raw material and KOH as activating agent through a one-step pyrolysis method. The prepared carbon-based material was systematically characterized by powder X-ray diffraction, scanning electron microscopy, N2 adsorption-desorption and Fourier-transform infrared spectroscopy. The results show that the three-dimensional ordered porous carbon materials prepared with KOH as the activator via pyrolysis possess abundant functional groups, high porosity, and high specific surface area, with a specific surface area of 1 471.6 m2·g-1. The three-dimensional ordered porous carbon materials prepared at 800 ℃ exhibits a high drug loading capacity (78.0%) and drug release rate (86.8%) for 5-fluorouracil. Three-dimensional orderly porous carbon materials show significant application advantages in drug construction, and their high specific surface area and adjustable pore size structure significantly improve the drug load rate and drug release rate, providing a solid foundation for the development of efficient and accurate drug delivery system.
