Advances in DNA origami intelligent drug delivery systems
10.16438/j.0513-4870.2024-0111
- VernacularTitle:DNA折纸智能药物递送系统的研究进展
- Author:
Zeng-lin YIN
1
,
2
;
Xi-wei WANG
3
;
Jin-jing CHE
3
;
Nan LIU
3
;
Hui ZHANG
3
;
Zeng-ming WANG
3
;
Jian-chun LI
1
;
Ai-ping ZHENG
3
Author Information
1. School of Pharmacy, Bengbu Medical University, Bengbu 233030, China
2. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
3. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
- Publication Type:Research Article
- Keywords:
DNA origami;
programmability;
rug delivery;
controllable design;
biomedicine
- From:
Acta Pharmaceutica Sinica
2024;59(10):2741-2750
- CountryChina
- Language:Chinese
-
Abstract:
DNA origami is a powerful technique for generating nanostructures with dynamic properties and intelligent controllability. The precise geometric shapes, high programmability, and excellent biocompatibility make DNA origami nanostructures an emerging drug delivery vehicle. The shape, size of the carrier material, as well as the loading and release of drugs are important factors affecting the bioavailability of drugs. This paper focuses on the controllable design of DNA origami nanostructures, efficient drug loading, and intelligent drug release. It summarizes the cutting-edge applications of DNA origami technology in biomedicine, and discusses areas where researchers can contribute to further advancing the clinical application of DNA origami carriers.
