Research progress on the application of membrane biomimetic nanocarriers in targeted therapy of lung diseases
10.16438/j.0513-4870.2023-1205
- VernacularTitle:膜仿生纳米载体在肺部疾病靶向治疗中应用研究进展
- Author:
Wen-jing BAI
1
;
Rong GUO
2
;
Lin XIONG
1
;
Leng-jing ZHU
1
;
Jia-xin LI
1
;
Ya-shi WANG
1
;
Man LI
1
;
Qin HE
1
Author Information
1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
2. West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China
- Publication Type:Research Article
- Keywords:
pulmonary disease;
lung targeted;
membrane;
biomimetic nanoparticle;
rug delivery system
- From:
Acta Pharmaceutica Sinica
2024;59(10):2730-2740
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary disease is one of the major threats to human health. However, the current clinical treatment drugs for lung diseases generally have problems such as low lung delivery efficiency, fast clearance rate and obvious toxic side effects. Recently, membrane biomimetic nanocarriers have attracted more and more attention. Due to their advantages of high targeting, long cycle time, good biocompatibility and strong immune escape ability, membrane biomimetic nanocarriers have become a major research hotspot in targeted therapy of lung diseases. In this review, we discuss the main preparation methods of membrane biomimetic nanoparticles, the characteristics of membrane biomimetic nanocarriers from different cell sources and their application in the targeted therapy of lung diseases. At the same time, according to the characteristics of different membranes, the shortcomings, current technical limitations and future prospects are discussed. This review is expected to provide references for the design of membrane biomimetic nanocarriers and their potential applications in the treatment of lung diseases.
