Discussion on the Scientific Connotation of Disease Mechanism of Stasis and Toxin Interaction of Liver Cancer based on Neutrophil Extracellular Traps
10.13288/j.11-2166/r.2024.23.002
- VernacularTitle:基于中性粒细胞胞外诱捕网论肝癌瘀毒互结病机的科学内涵
- Author:
Rui QIANG
1
;
Shuang LI
1
;
Wenliang LYU
2
;
Guowang YANG
3
Author Information
1. Shunyi Hospital，Beijing Hospital of Traditional Chinese Medicine，Beijing，101300
2. Guang'anmen Hospital，China Academy of Chinese Medical Sciences
3. Beijing Hospital of Traditional Chinese Medicine，Capital Medical University
- Publication Type:Journal Article
- Keywords:
liver cancer;
stasis and toxin interaction;
neutrophil extracellular traps;
disease mechanism
- From:
Journal of Traditional Chinese Medicine
2024;65(23):2394-2398
- CountryChina
- Language:Chinese
-
Abstract:
This article is to illustrate the connection between neutrophil extracellular traps （NETs） and stasis-toxin interactions during the development of liver cancer， and to provide ideas for the prevention and treatment of liver cancer. It is believed that the mechanism of tumor-related thrombosis formation caused by NETs is closely related to "stasis" in traditional Chinese medicine （TCM）， and the continuous maintenance or enhancement of tumor microenvironment by NETs is closely related to "toxin" in TCM； the strong coagulation-promoting effect of NETs makes the local microenvironment， which can be regarded as the toxin caused by blood stasis； the changes of tumor microenvironment induced by NETs further induced platelet aggregation， which may present a state of stasis caused by toxin； the pathological changes of liver cancer caused by NETs can be regarded as the microscopic manifestation of the mechanism of stasis-toxin interaction of liver cancer.
