Effects of MT-1207 on blood glucose,blood lipids and atherosclerosis in mice
10.12206/j.issn.2097-2024.202306011
- VernacularTitle:MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用
- Author:
Xiuping ZHANG
1
;
Jiasheng TIAN
;
Daoxin WANG
;
Jiaxin LI
;
Pin WANG
;
Chaoyu MIAO
Author Information
1. 海军军医大学药学系药理学教研室,上海 200433
- Keywords:
MT-1207;
losartan;
atherosclerosis;
blood glucose;
blood lipids
- From:
Journal of Pharmaceutical Practice and Service
2024;42(11):487-494
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of MT-1207 on blood glucose,blood lipids and atherosclerosis in mice.Methods The apolipoprotein E knockout(ApoE-/-)mice were fed with normal feed,drug feed containing losartan and drug feed containing MT-1207 at a dosage of 30 mg/kg.The body weight,blood glucose and blood lipids were detected,and the plaque area of atherosclerotic was evaluated.8-week-old male C57 mice were fed a high fat diet and given intragastric administration of MT-1207 and losartan at a dose of 30 mg/kg per day.The body weight,blood glucose and lipids levels were also examined to further evaluate the effects of MT-1207 on blood glucose and lipids levels.Results ApoE-/-mice treated with MT-1207 and losartan gained weight faster.There was no significant improvement in blood glucose and lipid levels,and no significant change in atherosclerotic plaque area.MT-1207 and losartan had no significant improvement effect on blood glucose and blood lipids of C57 mice.Conclusion MT-1207 and losartan couldn't improve the levels of blood glucose,blood lipids and atherosclerosis,and couldn't aggravate atherosclerosis.
