Research progress in the treatment of recurrent breast cancer with re-irradiation and hyperthermia
10.13491/j.issn.1004-714X.2024.05.021
- VernacularTitle:再程放疗与热疗联合治疗复发性乳腺癌研究进展
- Author:
Tiantian CHANG
1
;
Wei DUAN
1
Author Information
1. Yan’an University Affiliated Hospital, Yan’an 716000 China.
- Publication Type:ReviewArticles
- Keywords:
Recurrent breast cancer;
Re-irradiation;
Radiotherapy technology;
Hyperthermia
- From:
Chinese Journal of Radiological Health
2024;33(5):615-620
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is one of the major cancers affecting women globally. Although the five-year survival rate is very high, it is one of the most common causes of cancer-related deaths. Surgery, systemic therapy, and radiotherapy are the three pillars of radical treatment of breast cancer. However, for breast cancer patients who have undergone initial radiotherapy, many experience relapse or develop secondary cancers in the previously treated areas. These patients need to be treated again, and re-irradiation and hyperthermia are important treatment methods for recurrent breast cancer. Radiotherapy can be combined with local hyperthermia to make tumor cells sensitive to radiation, thereby reducing the required radiation dose. The combination of mild local hyperthermia and re-irradiation with reduced total dose is a treatment option for breast cancer patients who have previously received radiation. The combination of re-irradiation and hyperthermia is currently a hotspot of comprehensive tumor treatment. This article summarizes the research progress on the sequence of recurrent breast cancer and the optimal temperature of hyperthermia in treatment with re-irradiation and hyperthermia. Specifically, this article reviews the definition and type of re-irradiation and hyperthermia, the common radiotherapy methods for various types of recurrent breast cancer, and the effect of radiotherapy, hyperthermia, or their combination on the immune phenotype of tumor cells and its mechanism. Our results provide a scientific basis for the evaluation of the optimal efficacy of re-irradiation combined with hyperthermia in treating recurrent breast cancer.
