Dosimetric comparison of volumetric modulated arc therapy plans with different X-ray energies in patients with cervical cancer
10.13491/j.issn.1004-714X.2024.05.014
- VernacularTitle:不同X射线能量在宫颈癌VMAT放疗中剂量学比较
- Author:
Chao YANG
1
;
Jihua HAN
1
;
Zhijian ZHU
1
;
Dongcheng HE
1
Author Information
1. The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300 China.
- Publication Type:OriginalArticles
- Keywords:
Cervical cancer;
Volumetric modulated arc therapy;
Dose;
Radiotherapy
- From:
Chinese Journal of Radiological Health
2024;33(5):573-577
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of volumetric modulated arc therapy (VMAT) with 6 MV and 10 MV X-ray photon energies in patients with cervical cancer. Methods From March 2019 to May 2020, 24 patients with cervical cancer who underwent radiation therapy in the Oncology Radiotherapy Department of our hospital were selected. VMAT plans with 6 MV and 10 MV photon energies were re-designed for each patient. The target parameters (D98%, D2%, Dmean), conformal index, and homogeneity index of the two groups were compared. The radiation doses received by the bladder, rectum, small intestine, left femoral head, right femoral head, and normal tissue other than planning target volume (Body-PTV), as well as monitor units and estimated total delivery time, were also compared. Results D2%, Dmean, homogeneity index, and monitor units were significantly lower in the 10 MV group than in the 6 MV group (50.78 ± 0.33 Gy vs. 50.35 ± 0.29 Gy; 49.05 ± 0.2 Gy vs. 48.93 ± 0.17 Gy; 0.08 ± 0.01 vs. 0.07 ± 0.01; 1179.26 ± 110.55 vs. 1099.3 ± 80.9). Comparison of organs at risk showed that compared with the 10 MV group, the 6 MV group demonstrated significantly lower V40Gy of the bladder, D5% of the right femoral head, and D2% and V5Gy of Body-PTV (60.37 ± 13.66 vs. 60.84 ± 13.88; 37.09 ± 5.43 Gy vs. 38.03 ± 5.68 Gy; 41.71 ± 1.39 Gy vs. 42.16 ± 1.31 Gy; 47.88 ± 9.75 vs. 48.23 ± 9.74). There were no significant differences in other parameters between the two groups. Conclusion The VMAT plans with 6 MV and 10 MV X-ray photon energies both meet the clinical needs of cervical cancer radiotherapy. The cervical cancer VMAT plan with 6 MV photon energy is recommended due to better protection of the organs at risk.
