Role of Mitophagy in Prevention and Treatment of Heart Failure Based on PINK1/Parkin Pathway and Treatment with Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241998
- VernacularTitle:基于PINK1/Parkin通路探讨线粒体自噬防治心力衰竭作用及中医药治疗进展
- Author:
Ziyang YUAN
1
;
Yan ZHANG
2
;
Wei ZHANG
3
;
Yaqin WANG
1
;
Wenjun MAO
1
;
Guo YANG
1
;
Xuewei WANG
1
Author Information
1. Liaoning University of Traditional Chinese Medicine （TCM），Shenyang 110847，China
2. The Affiliated Hospital of Liaoning University of TCM，Shenyang 110000，China
3. Shenyang Pharmaceutical University，Shenyang 110016，China
- Publication Type:Review
- Keywords:
heart failure;
mitochondrial autophagy;
PTEN-induced putative kinase 1 （PINK1）/Parkin;
action mechanism;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(24):262-271
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is a group of complex clinical syndromes that represent the final stage of cardiovascular disease development， characterized by an extremely high mortality rate. However， due to the complexity of the pathological mechanisms， an effective treatment method has not yet been found. Mitochondria are among the most critical organelles in cells， playing an essential role in energy supply and widely participating in various life activities， such as the regulation of oxidative stress and apoptosis. The normal functioning of mitochondria is crucial for maintaining the body's normal life activities. In recent years， studies have found that mitochondrial dysfunction is associated with the occurrence and progression of various diseases， particularly closely related to the onset of heart failure. An imbalance in mitochondrial homeostasis is a key factor in cardiomyocyte death and the onset of heart failure. Mitochondrial autophagy， as a means of regulating mitochondrial homeostasis， is significant for the prevention and treatment of heart failure. Traditional Chinese medicine （TCM） therapy is a unique treatment approach in China now widely applied in clinical practice， demonstrating significant efficacy in treating heart failure， with unique advantages. Modern pharmacological research indicates that Chinese medicine monomers and compounds can target and regulate mitochondrial homeostasis in cardiomyocytes， affect mitochondrial autophagy， and protect cardiomyocytes， though the specific mechanisms remain unclear. Therefore， this paper explored the mechanisms of the PTEN-induced putative kinase 1 （PINK1）/Parkin pathway in mitochondrial autophagy and heart failure， reviewed the effects of PINK1/Parkin-mediated mitochondrial autophagy on heart failure， and discussed the therapeutic effects of PINK1/Parkin-mediated mitochondrial autophagy on heart failure in conjunction with TCM. This paper is expected to provide new ideas and methods for the prevention and treatment of heart failure from the perspective of PINK1/Parkin regulation of mitochondrial autophagy.
