Dahuang Huanglian Xiexintang and Its Modified Prescription Improve Type 2 Diabetes Mellitus： A Review
10.13422/j.cnki.syfjx.20242323
- VernacularTitle:大黄黄连泻心汤及其加减方改善2型糖尿病研究进展
- Author:
Dong AN
1
;
Yanhui ZHAI
1
;
Yankui GAO
1
;
Rong LIU
2
;
Qi ZHOU
1
;
Xiangdong ZHU
3
;
Yonglin LIANG
1
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Jiangxi University of Chinese Medicine， Nanchang 330000， China
3. Ningxia Medical University， Yinchuan 750000， China
- Publication Type:Journal Article
- Keywords:
type 2 diabetes mellitus;
Dahuang Huanglian Xiexintang;
insulin resistance;
glycolipid metabolism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(24):141-151
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus （T2DM） is based on insulin resistance （IR） and insulin secretion deficiency， with the specific mechanisms still unclear. Current research involves mechanisms such as glycolipid toxicity， inflammatory response， oxidative stress damage， and mitochondrial dysfunction. Modern traditional Chinese medicine （TCM） scholars have named it "blood glucose collateral disease" based on the clinical characteristics and natural progression of T2DM. This condition is primarily manifested as abnormal blood sugar levels in the early stages， and as the disease progresses， it gradually causes widespread damage to the body's veins and collaterals， ultimately leading to lesions in vessels and collaterals. Among these， "spleen heat" （obesity type） is the most common clinical type of T2DM. The concept of "internal heat-induced elimination" runs through both the onset and complications of T2DM， with internal heat being a key factor in its pathogenesis. The clinical application of Dahuang Huanglian Xiexintang and its modifications has achieved significant therapeutic effects. This paper reviews the origins and treatment characteristics of Dahuang Huanglian Xiexintang， along with clinical application research and experimental studies related to T2DM treatment， involving mechanisms for regulating glucose and lipid metabolism disorders， improving IR， modulating inflammatory responses， combating oxidative stress damage， regulating autophagy-related signaling pathways， modulating intestinal flora， inhibiting pyroptosis， and alleviating endoplasmic reticulum stress， with the purpose to provide direction for further research on the prevention and treatment of T2DM and its related complications， to offer reference for developing Dahuang Huanglian Xiexintang as a rapid hypoglycemic Chinese patent medicine for obese T2DM， and to better guide the clinical promotion of this drug.
