Correlation of CD200-CD200R axis and diseases and its research progress
- VernacularTitle:CD200-CD200R轴与疾病的相关性及其研究进展
- Author:
Han XU
1
;
Yu-xin BI
2
;
Gui-xia LI
2
;
Jian LI
2
;
Liu-li WANG
2
;
Rui-jia HAO
2
;
Xue-min ZHENG
2
;
Rui-jing HUANG
2
;
Jin HAN
2
;
Fei LI
1
;
Gen-bei WANG
2
Author Information
- Publication Type:Research Article
- Keywords: CD200; CD200R; isease; targeted drug; immune checkpoint
- From: Acta Pharmaceutica Sinica 2024;59(4):822-830
- CountryChina
- Language:Chinese
- Abstract: CD200 and its receptor CD200R constitute an endogenous inhibitory signal. The binding of CD200 and CD200R can regulate the immune response to pathogenic stimuli, which has received much attention in recent years. It has been found that CD200-CD200R is involved in the regulation of many kinds of pathological inflammation, including autoimmune diseases, cardiac cerebrovascular disease, infection and tumor. This paper reviews the protein structure, distribution, expression, biological function of CD200-CD200R and the correlation with diseases, and analyses the current status and development ideas of CD200-CD200R as drug targets. It aims to provide theoretical support for new drug research and development based on this target.
