Study on the chemical constituents of triterpenoids in <italic>Patrinia villosa</italic> Juss.

Qi-guo WU; Le-yi Huang; Zhi Chen; Dong-feng Liu; Yong-li Wang; Gui-xin Chou

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Study on the chemical constituents of triterpenoids in Patrinia villosa Juss.

VernacularTitle:白花败酱中三萜类化学成分研究
Author: Qi-guo WU ^{1
,

2
,

3} ; Le-yi HUANG ^{3
,

4
,

5} ; Zhi CHEN ¹ ; Dong-feng LIU ⁶ ; Yong-li WANG ^{3
,

4} ; Gui-xin CHOU ^{2
,

3
,

7}
Author Information

1. Department of Pharmacy, Anqing Medical College, Anqing 246052, China
2. Shanghai R&
3. D Centre for Standardization of Chinese Medicines, Shanghai 201203, China
4. Shanghai R&
5. State Key Lab. of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry Co., Ltd., China State Institute of Pharmaceutical Industry, Shanghai 201203, China
6. Anqing food and drug inspection Center, Anqing 246000, China
7. Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Publication Type:Research Article
Keywords: italic>Patrinia villosa Juss.; triterpenoid; anti-inflammatory; chemical constituent
From: Acta Pharmaceutica Sinica 2024;59(4):1005-1009
CountryChina
Language:Chinese
Abstract: Seven triterpenoids were isolated and purified from the 95% aqueous EtOH extract whole plants of P. villosa by various chromatographic techniques, such as silica gel, ODS, Sephadex LH-20 gel column chromatography and preparative high performance liquid chromatography. Based on physicochemical properties and spectral analyses, the structures of the seven compounds were identified as 29-acetoxyoleanolic acid-3-O-α-L-arabinopyranoside (1), oleanolic acid (2), 3β-hydroxy-24-norursa-4(23),12,20(30)-trien-28-oic acid (3), 3β-hydroxy-24-nor-urs-4(23),12-dien-28-oic acid (4), ursolic acid (5), hederagenin (6), oleanolic acid 3-O-arabinoside (7). Compound 1 is a new compound. Compounds 3, 4, 6, and 7 are isolated from P. villosa for the first time. All compounds were assayed for their anti-inflammatory activity by the prodution of NO in lipopolysaccharide-stimulated RAW 264.7 cells. The results showed that compounds 1, 2, 3, 4, 6, and 7 significantly inhibited the NO release.