Research progress on carrier-free and carrier-supported supramolecular nanosystems of traditional Chinese medicine anti-tumor star molecules
10.16438/j.0513-4870.2023-1169
- VernacularTitle:中药抗肿瘤明星分子无载体和有载体超分子纳米体系研究进展
- Author:
Zi-ye ZANG
;
Yao-zhi ZHANG
;
Yi-hang ZHAO
;
Xin-ru TAN
;
Ji-chang WEI
;
An-qi XU
;
Hong-fei DUAN
;
Hong-yan ZHANG
;
Peng-long WANG
;
Xue-mei HUANG
;
Hai-min LEI
- Publication Type:Research Article
- Keywords:
anti-tumor;
supramolecular;
carrier-free;
carrier;
star molecule of traditional Chinese medicine
- From:
Acta Pharmaceutica Sinica
2024;59(4):908-917
- CountryChina
- Language:Chinese
-
Abstract:
Anti-tumor traditional Chinese medicine has a long history of clinic application, in which the star molecules have always been the hotspot of modern drug research, but they are limited by the solubility, stability, targeting, bioactivity or toxicity of the monomer components of traditional Chinese medicine anti-tumor star molecules and other pharmacokinetic problems, which hinders the traditional Chinese medicine anti-tumor star molecules for further clinical translation and application. Currently, the nanosystems prepared by supramolecular technologies such as molecular self-assembly and nanomaterial encapsulation have broader application prospects in improving the anti-tumor effect of active components of traditional Chinese medicine, which has attracted extensive attention from scholars at home and abroad. In this paper, we systematically review the research progress in preparation of supramolecular nano-systems from anti-tumor star molecule of traditional Chinese medicine, and summarize the two major categories and ten small classes of carrier-free and carrier-based supramolecular nanosystems and their research cases, and the future development direction is put forward. The purpose of this paper is to provide reference for the research and clinical transformation of using supramolecular technology to improve the clinical application of anti-tumor star molecule of traditional Chinese medicine.
