Discrete element modeling and breakage behavior analysis of oral solid dosage form particles
10.16438/j.0513-4870.2023-0980
- VernacularTitle:口服固体制剂颗粒的离散元建模与破碎行为分析
- Author:
Lin-xiu LUO
1
;
Tian-bing GUAN
1
;
An-qi LUO
1
;
Zeng LIU
1
;
Yu-ting WANG
1
;
Yan-ling JIANG
1
;
Zheng LU
1
;
Jing-cao TANG
1
;
Shuang-kou CHEN
1
;
Hui-min SUN
2
;
Chuan-yun DAI
1
Author Information
1. School of and Chemical Engineering, Chongqing University of Science and Technology, Chongqing Key Laboratory of Pharmaceutical Digitalization, Chongqing 401331, China
2. National Institutes for Food and Drug Control, Beijing 100050, China
- Publication Type:Research Article
- Keywords:
particle;
iscrete element modeling;
bonding model;
breakage law
- From:
Acta Pharmaceutica Sinica
2024;59(4):1057-1066
- CountryChina
- Language:Chinese
-
Abstract:
The breakage pattern of unit particles during the production of oral solid dosage forms (OSD) is closely related to the quality of intermediate or final products. To accurately characterize the particles and study the evolution law of particle breakage, the Bonding model of the discrete element method (DEM) was used to investigate the breakage patterns of model parameters, particle shape and process conditions (loading mode and loading rate) on the dynamic breakage, force-time curve, breakage rate, maximum breakage size ratio and fracture strength of particles. The results showed that the particle breakage force was positively correlated with normal strength and bonded disk scale, negatively correlated with normal stiffness per unit area and tangential stiffness per unit area, and weakly correlated with tangential strength. The particle breakage rate was negatively correlated with the aspect ratio of the particles, and the maximum breakage size ratio was positively correlated with the aspect ratio of the particles; among the three loading modes, the breakage rate of compression breakage model was the largest, the breakage rate of shear breakage model was the second largest, and the breakage rate of wear breakage model was the smallest; the maximum breakage size ratio was positively correlated with the loading rate, the loading mode and the loading rate had no mutual influence on particle breakage rate, but had mutual influence on the maximum breakage size ratio. The research results will provide a theoretical basis for the shift of OSD from batch manufacturing to advanced manufacturing.
