Advances in HIV-1 latency-regulating agents
10.16438/j.0513-4870.2023-0937
- VernacularTitle:HIV-1潜伏库调控剂的研究进展
- Author:
Jiao-jiao DAI
;
Xiang-yi JIANG
;
Da FENG
;
Hao LIN
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
acquired immune deficiency syndrome;
HIV-1 latent reservoirs;
functional cure;
shock and kill;
block and lock
- From:
Acta Pharmaceutica Sinica
2024;59(4):840-852
- CountryChina
- Language:Chinese
-
Abstract:
At present, there is no cure for acquired immune deficiency syndrome (AIDS) due to HIV-1 latent reservoirs. Therefore, it urgently requires novel HIV-1 latency-regulating agents with high potency, low toxicity and favorable drug-like properties to achieve a functional cure for AIDS. Herein, we reviewed the advances in HIV-1 latency-regulating agents since 2019, including the drug discovery strategies, bioactivities, and mechanisms of these compounds. It is of great guiding significance in the development of latency-regulating agents with clinical value.
