Advances in the relationship between perivascular adipose tissue and vascular calcification
10.16438/j.0513-4870.2023-1364
- VernacularTitle:血管周围脂肪组织与血管钙化关系的研究进展
- Author:
Dong-xue WU
;
Ming XU
- Publication Type:Research Article
- Keywords:
perivascular adipose tissue;
vascular calcification;
adipokine;
inflammation;
mesenchymal stem cell;
browning
- From:
Acta Pharmaceutica Sinica
2024;59(6):1527-1537
- CountryChina
- Language:Chinese
-
Abstract:
Vascular calcification (VC) is a chronic systemic vascular disease characterized by abnormal deposition of hydroxyapatite minerals in the vascular system and is closely associated with aging, diabetes, atherosclerosis, and chronic kidney disease. Perivascular adipose tissue (PVAT), a special type of adipose tissue that surrounds blood vessels, is thought to be a supportive component of the vascular structure and is capable of playing a role in homeostatic regulation during vasodilatation and contraction. Currently, there is growing evidence that perivascular adipose tissue acts as an endocrine and paracrine organ and interacts closely with cellular components of the vascular wall, which may be involved in the development of vascular calcification. This article reviews the role of perivascular adipose tissue in the pathophysiological process of vascular calcification and its potential as a target for therapeutic intervention, with the aim of providing new ideas for the prevention and treatment of vascular calcification.