Advances in the construction of models and applications of Alzheimer's disease based on microfluidic chips
10.16438/j.0513-4870.2023-1354
- VernacularTitle:基于微流控芯片的阿尔茨海默病模型构建和应用研究进展
- Author:
Piao-xue YOU
1
;
Lan CHEN
1
;
Shu-qi SHEN
2
;
Liang CHAO
2
;
Hui WANG
2
;
Zhan-ying HONG
1
,
3
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. School of Pharmacy, Naval Medical University, Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, China
3. School of Pharmacy, Naval Medical University, Shanghai Key Laboratory for Pharmaceutical Metabolite Research, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
microfluidic chip;
Alzheimer's disease;
model construction;
pathological mechanism;
rug screening
- From:
Acta Pharmaceutica Sinica
2024;59(6):1569-1581
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with dysfunctions related to thinking, learning, and memory of the brain. AD has multiple pathological characteristics with complicated causes, constructing a suitable pathological model is crucial for the research of AD. Microfluidic chip technology integrates multiple functional units on a chip, which can realize microenvironmental control similar to the physiological environment. It is well applied in the construction of pathological model, early diagnosis as well as drug screening of AD. This paper focuses on the construction of AD microfluidic chips model from the perspective of cell type, culture formats and the chips structure as well as the research progress of microfluidic chips in AD application based on the pathological characteristics of AD, which will provide a reference for further elucidation of AD mechanism and drug development.
