Cushing disease in a patient with double pituitary adenomas complicated with diabetes insipidus: A case report
https://doi.org/10.15605/jafes.039.02.05
- Author:
Waye Hann Kang
1
,
2
,
3
;
Ida Ilyani Adam
3
,
4
;
Norasyikin A. Wahab
2
,
3
Author Information
1. University Tunku Abdul Rahman (UTAR), Selangor, Malaysia
2. Faculty of Medicine, Universiti Kebangsaan Malaysia
3. Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Malaysia
4. Ministry of Health Malaysia
- Publication Type:Case Reports
- Keywords:
double pituitary adenoma;
adrenocorticotropic hormone-secreting pituitary adenoma
- MeSH:
Pituitary ACTH Hypersecretion;
Cushing disease;
Diabetes Insipidus
- From:
Journal of the ASEAN Federation of Endocrine Societies
2024;39(2):97-102
- CountryPhilippines
- Language:English
-
Abstract:
Managing a patient with both pituitary hypersecretory and hyposecretory manifestations may be perplexing. We report a 14-year-old female who presented with weight gain, polyuria and polydipsia. Biochemical results were consistent with Cushing disease with central diabetes insipidus. Pituitary magnetic resonance imaging showed right adenoma with stalk thickening. The immunohistochemistry staining of both adenomas was positive for adrenocorticotropic hormone, thyroid stimulating hormone, growth hormone and luteinizing hormone. Postoperatively, the patient developed panhypopituitarism with persistent diabetes insipidus. The coexistence of double adenomas can pose diagnostic and management challenges and is a common cause of surgical failure. Intraoperative evaluation is important in the identification of double or multiple pituitary adenomas in a patient presenting with multiple secretory manifestations.
- Full text:202411291511168769711_6pp.pdf
