Role of microglial polarization in age-related macular degeneration
10.3980/j.issn.1672-5123.2024.12.02
- VernacularTitle:小胶质细胞极化在年龄相关性黄斑变性中的作用
- Author:
Yichi* ZHANG
1
;
Xiuxia* YANG
1
;
Pingping LIU
1
;
Mengjie LIU
1
;
Wenting LUO
1
;
Yang LIU
1
;
Chengcheng YANG
1
Author Information
1. Department of Ophthalmology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000,Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
microglia polarization;
choroidal neovascularization;
inflammation;
oxidative stress;
macular degeneration
- From:
International Eye Science
2024;24(12):1863-1872
- CountryChina
- Language:Chinese
-
Abstract:
Microglia, originating from primitive macrophages in the yolk sac, serves as both immune system defenders and regulators of homeostasis. These cells exhibit two primary polarization states: conventionally activated(M1)and alternatively activated(M2). The polarization of microglia plays a crucial role in influencing inflammatory disorders, metabolic imbalances, and neural degeneration. This process is implicated in various aspects of ocular diseases, especially age-related macular degeneration(AMD), including inflammation, oxidative stress and pathological angiogenesis. The distinct functional phenotypes of microglia impact disease progression and prognosis. Thus, regulating the polarization or functional phenotype of microglia at different stages of AMD holds promise for personalized therapeutic approaches. This comprehensive review outlines the involvement of microglia polarization in both physiological and pathological conditions, emphasizing its relevance in AMD. The discussion underscores the potential of polarization as a foundation for personalized treatment strategies for AMD.
