Effect of maternal iodine excess during pregnancy on neonatal thyroid function and neurodevelopmental status at 12 weeks
https://doi.org/10.15605/jafes.039.02.12
- Author:
Deepashree K Rao
1
;
Ankur Jindal
1
;
Aashima Dabas
1
;
Haseena Sait
1
;
Sangeeta Yadav
1
;
Seema Kapoor
1
Author Information
1. Maulana Azad Medical College
- Publication Type:Journal Article
- Keywords:
iodinization;
hyperthyrotropinemia;
urine iodine concentration
- MeSH:
Thyroid;
Thyroid Gland;
Hypothyroidism;
Thyroid Function Tests
- From:
Journal of the ASEAN Federation of Endocrine Societies
2024;39(2):27-32
- CountryPhilippines
- Language:English
-
Abstract:
Objective:This study aims to determine the effect of iodine excess in pregnant mothers on thyroid function, growth and neurodevelopment in the neonates when assessed at 12 weeks of age.
Methodology:This prospective study enrolled term neonates with birth weight >2500 gm of mothers having urine iodine concentration (UIC) ≥500 µg/L documented in the third trimester of the peripartum period. Neonatal TSH was collected by heel prick on dried blood spots within 24-72 hours of age and measured by time-resolved fluroimmunoassay. Neonates with TSH ≥11 mIU/L at birth were followed up at 2 and 12 weeks to monitor thyroid dysfunction, growth and development.
Results:A total of 2354 (n = 1575 in the delivery room) maternal urine samples were collected of which 598 (25.4%) had elevated UIC. Forty-nine (12.2%) neonates had TSH ≥11mIU/L on newborn screening of whom 18 and 3 neonates had residual elevated TSH at 2 and 12 weeks of life, respectively. Maternal iodine levels correlated weakly with TSH at 2 weeks (rho = 0.299; p = 0.037). No child required treatment for congenital hypothyroidism. Eight babies additionally had TSH >5 mIU/L at 12 weeks of life. The growth and development of babies with or without TSH elevation was comparable at three months (p > 0.05).
Conclusion:Maternal iodine excess in pregnancy and peripartum period causes transient hyperthyrotropinemia in neonates that did not affect the growth and development at 3 months of age.
- Full text:20241129105946677946pp.pdf
