Protective effect and mechanism of adiponectin on myocardial inj ury in septic mice

Luqian Liu; Ling Chen; Xuqing Qin; Wenjun He; Rui Yang; Liya Shan; Xinzhi Li; Ketao Ma

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Protective effect and mechanism of adiponectin on myocardial inj ury in septic mice

Author: Luqian Liu ^{1
,

2} ; Ling Chen ¹ ; Xuqing Qin ^{1
,

3} ; Wenjun He ^{1
,

2} ; Rui Yang ^{1
,

3} ; Liya Shan ^{1
,

3} ; Xinzhi Li ¹ ; Ketao Ma ^{1
,

3}
Author Information

1. Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine , Shihezi 832000
2. Dept of Pathophysiology, Shihezi University School of Medicine , Shihezi 832000
3. Dept ofPhysiology, Shihezi University School of Medicine , Shihezi 832000
Publication Type:Journal Article
Keywords: apoptosis; adiponectin; connexin43; lipopolysaccharide; septic myocardial injury
From: Acta Universitatis Medicinalis Anhui 2022;57(1):36-40
CountryChina
Language:Chinese
Abstract: Objective :To investigate the protective effect of adiponectin APN on myocardial injury caused by sep⁃ sis and its possible mechanism.
Methods
Results :Compared with sham group , the expression of Bax , cleaved Caspase3 protein increased and the expression of Bcl⁃2 protein decreased in LPS group. Compared with LPS group , the injury in APN + LPS group was significantly alleviated , showing that the expression of Bax , cleaved caspase3 protein decreased and the expression of Bcl⁃2 protein increased. Meanwhile , compared with sham group , the expression of Cx43 increased in LPS group and decreased in APN + LPS group.
Conclusion :Adiponectin can attenuate LPS⁃induced cardiac injury in septic mice. The mechanism may be through the inhibition of apoptotic signal pathway and the expression of Cx43.
Full text:2024112817133348881脂联素对脓毒症小鼠心肌损伤的保护作用及其机制_刘鲁倩.pdf