Research progress on the application of two-dimensional MXenes in stomatology
10.12016/j.issn.2096-1456.202330410
- VernacularTitle:二维MXenes在口腔医学中应用的研究进展
- Author:
Si HUANG
1
;
Yongjin ZHONG
;
Anchun MO
Author Information
1. 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔种植科,四川 成都(610041)
- Keywords:
MXene;
nanomaterials;
biocompatibility;
stomatology;
bone tissue engineering;
bone regenera-tion;
caries;
antibacterial;
drug loading;
oral tumor;
periodontitis;
treatment monitoring
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(11):901-906
- CountryChina
- Language:Chinese
-
Abstract:
MXenese is a type of two-dimensional inorganic compound in materials science that is composed of transi-tion metal carbides,nitrides,or carbonitrides with several atomic layer thicknesses.Owing to the presence of hydroxyl groups or terminal oxygen groups on the surface of MXene materials,they exhibit metallic conductivity similar to that of transition metal carbides.Owing to their excellent optical,mechanical,electrothermal,and biocompatible properties,emerging 2D MXenes are widely used in biomedical fields such as tissue engineering,antimicrobial drugs,photothermal therapy,drug/gene delivery,sensing,and regenerative medicine.In this paper,we review the methods for synthesizing and modifying MXene-based composites,their research and application in stomatology,and their development prospects and challenges in the clinical application of tissue engineering.The biocompatibility and osteogenic properties of MX-ene and its nanocomposites have the potential to promote cell proliferation and bone regeneration.The anti-bacterial ad-hesion and biofilm formation properties can be applied to implant coating and prevent caries.The excellent photother-mal,conductive,and mechanical sensitivity of this agent make it suitable for drug delivery,bio-photothermal therapy,immune signal sensing,and gene detection.On this basis,MXene has recently achieved outstanding results in the fields of stomatology,including bone tissue engineering,antimicrobial,drug delivery,physical and mechanical enhancement of dental biomaterials,oral cancer treatment,and periodontal disease monitoring.However,research on the prevention and treatment of refractory oral diseases has not yet been reported.At present,the properties and surface modification of MXene-based nanomaterials are relatively well understood.Future studies should focus on the dose-dependent biosafety,cellular and molecular mechanisms,and signaling pathways of MXene to fully exploit its unique advantages in oral clini-cal and tissue engineering fields.
