Research progress on macrophage polarization,pyroptosis,and efferocytosis in periodontitis
10.12016/j.issn.2096-1456.202330511
- VernacularTitle:牙周炎中巨噬细胞极化、焦亡、胞葬的研究进展
- Author:
Xinran HE
1
;
Yuan LI
;
Wuyang ZHANG
;
Ying AN
;
Yang XUE
Author Information
1. 口颌系统重建与再生全国重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔疾病临床医学研究中心,空军军医大学口腔医院颌面外科,陕西西安(710032)
- Keywords:
periodontitis;
macrophage;
innate immunity;
polarization;
pyroptosis;
efferocytosis;
metabolic reprogramming;
inflammasome;
NF-κB signaling pathway
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2024;32(11):886-893
- CountryChina
- Language:Chinese
-
Abstract:
The irreversible destruction of periodontal tissue caused by periodontitis is the result of an imbalance be-tween external pathogenic factors and the internal immune response.As human immune cells,macrophages have both pro-and anti-inflammatory roles in the occurrence and development of periodontitis.Pathogenic bacteria,inflammatory cytokines,and neutrophils in the periodontal microenvironment can significantly affect the metabolism and functional status of macrophages,and the status of macrophages can regulate disease processes.By activating the NF-κB signaling pathway,the bacteria cause macrophages to undergo M1 proinflammatory polarization and pyroptosis,forming a microen-vironment that induces periodontal tissue destruction.With the development of the disease,numerous apoptotic neutro-phils are recognized and phagocytized by macrophages(i.e.efferocytosis),which can both inhibit the NF-κB pathway and activate the nuclear receptors PPAR and LXR,promoting the anti-inflammatory polarization of M2 and further en-hancing the efferocytosis activity of macrophages.As a result,these treatments can limit tissue inflammatory damage and promote tissue repair.In recent years,periodontitis treatment strategies focusing on macrophage regulation have re-ceived extensive attention,including gene knockout,nanoparticles,exosomes,miRNA,and polyunsaturated fatty acid di-ets.In this article,we review the specific role of macrophages in periodontitis from three aspects,including macrophage polarization,pyroptosis,and efferocytosis,which may improve our understanding of periodontitis and provide possible di-rections for periodontitis treatment strategies.
- Full text:2024112215160590786牙周炎中巨噬细胞极化 焦亡 胞葬的研究进展.pdf
