Relationship between the expression of biomarkers in the activated innate immune cell and vital organs injuries during the cardiopulmonary bypass
- VernacularTitle:体外循环中先天性免疫细胞活化标志物表达与重要器官损伤
- Author:
Wen XIONG
1
;
Jinghan ZHANG
2
;
Lei DU
3
;
Xiaoling HU
1
Author Information
1. The First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan, P. R. China
2. School of Anaesthesia, Zunyi Medical University, Zunyi, 563000, Guizhou, P. R. China
3. Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
inflammatory response;
biomarkers;
organ injury;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(11):1679-1683
- CountryChina
- Language:Chinese
-
Abstract:
Although great progress has been achieved in the techniques and materials of cardiopulmonary bypass (CPB), cardiac surgery under CPB is still one of the surgeries with the highest complication rate. The systemic inflammatory response is an important cause of complications, mainly characterized by activation of innate immune cells and platelets, and up-regulation of inflammatory cytokines. After activation, a variety of molecules on the membrane surface are up-regulated or down-regulated, which can amplify tissue inflammatory damage by releasing cytoplasmic protease and reactive oxygen species, and activate multiple inflammatory signaling pathways in the cell, ultimately leading to organ dysfunction. Therefore, the expression of these cell membrane activation markers is not only a marker of cell activation, but also plays an important role in the process of vital organ injury after surgery. Identification of these specific activation markers is of great significance to elucidate the mechanisms related to organ injury and to find new prevention and treatment methods. This article will review the relationship between these activated biomarkers in the innate immune cells and vital organ injuries under CPB.
