Research progress on signal pathways in pathogenesis of acute lung injury and the drug intervention
- VernacularTitle:急性肺损伤发病机制相关信号通路及其药物干预的研究进展
- Author:
Sihao YANG
1
;
Hongxin NIE
2
;
Hui MENG
1
Author Information
1. Department of Cardiothoracic Surgery, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, 519100, Guangdong, P. R. China
2. Department of Emergency, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, Liaoning, P. R. China
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
signal pathway;
inflammatory reaction;
oxidative stress;
review
- From:
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
2024;31(09):1356-1362
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury (ALI), in which various factors inside and outside the lung lead to hypoxemic respiratory insufficiency and even the development of acute respiratory distress syndrome, has a high morbidity and mortality rate, and its pathogenesis is characterized by complex signaling pathways and limited therapeutic options. A large number of studies have reported that nuclear factor kappa B (NF-κB), phosphatidylinositol 3-kinase (PI3K)/Akt, mitogen-activated protein kinase (MAPK), AMP-activated protein kinase (AMPK), vascular endothelial growth factors (VEGF) and JAK/signal transducer and activator of transcription (STAT) signaling pathways are all related to the inflammatory response of ALI, and they are involved in regulating the inflammatory response process of ALI individually or cooperatively. Therefore, this article reviews the research progress on the pathogenesis-related signaling pathways and the drug interventions, aiming to provide a reference for early intervention in lung injury, optimizing the donor pool to increase the proportion of donation after cardiac death and providing quality donor protection conditions.
