Research advances in solubility-enhancing formulation technologies for progesterone
- VernacularTitle:黄体酮增溶制剂技术研究进展
- Author:
Tingting JIANG
1
;
Yunyun WANG
2
;
Xiangxiang WU
2
;
Huahui ZENG
2
;
Xin ZHU
1
Author Information
1. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450018，China
2. Academy of Chinese Medical Sciences，Henan University of Chinese Medicine，Zhengzhou 450018，China
- Publication Type:Journal Article
- Keywords:
progesterone;
preparation method;
solubility;
bioavailability;
solubility-enhancing formulation technology
- From:
China Pharmacy
2024;35(21):2703-2708
- CountryChina
- Language:Chinese
-
Abstract:
Progesterone is currently the first-line drug for clinical treatment and prevention of threatened abortion and habitual abortion. However， due to its special chemical structure， its solubility is low， which limits its clinical application. Therefore， the new technology and new dosage form of progesterone solubilization preparation is an important direction of its research and development. In this paper， the research progress of progesterone solubilization preparation technology in recent years is reviewed. It is found that the water solubility of progesterone can be enhanced by solid dispersion technology， inclusion technology， micronization， nanocrystallization （ including nanosuspensions， polymer micelles， nanoparticles， etc. ）， liposome technology， self- emulsification， cocrystal technology， and 3D printing. Eight technologies are used to increase the solubility of progesterone， improve its bioavailability and reduce its toxic and side effects， to serve the clinic better.
