Research progress on the prevention and treatment of sepsis by intervening in JAK/STAT signaling pathway with traditional Chinese medicine
- VernacularTitle:中药干预JAK/STAT信号通路防治脓毒症的研究进展
- Author:
Zhu LIU
1
;
Jiawei WANG
1
;
Yijun FANG
1
;
Jinchan PENG
1
;
Liqun LI
2
;
Sheng XIE
2
Author Information
1. School of Graduate，Guangxi University of Chinese Medicine，Nanning 530001，China
2. Center for Preventive Treatment of Disease，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
sepsis;
JAK/STAT signaling pathway;
inflammatory response
- From:
China Pharmacy
2024;35(21):2697-2702
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a life-threatening organ dysfunction caused by infection. Janus kinase/signal transducer and activator of transcription （JAK/STAT） signaling pathway plays a key role in the regulation of inflammatory response， oxidative stress and apoptosis. Some traditional Chinese medicine monomers， such as flavonoids （such as taxifolin）， alkaloids （such as sinomenine）， and stilbenes （such as piceatannol） can exert anti-inflammatory， anti-oxidation， and inhibition of apoptosis by regulating the JAK/ STAT signaling pathway， which is helpful to improve sepsis. Traditional Chinese medicine compounds （such as Zuojinfang） and traditional Chinese medicine injections （such as Astragalus injection， Xuebijing injection） can also inhibit inflammation， protect organ function， and reduce sepsis-related damage by regulating JAK/STAT signaling pathway. Although traditional Chinese medicine has shown great potential in the prevention and treatment of sepsis， the current research mainly focuses on in vitro and animal models， and more relative clinical researches need to be conducted.
