Clinical evaluation of elderly patients with sarcopenia receiving Shenling baizhu powder combined with nutrition and exercise intervention
- VernacularTitle:老年肌少症患者接受参苓白术散联合营养支持和运动干预的临床评价
- Author:
Huanhuan JIANG
1
;
Dong CHEN
2
;
Aishuang FU
3
;
Yanlei GE
3
;
Qiang WANG
4
;
Shizi LI
4
;
Huiqin SHEN
4
;
Xia LI
4
;
Yingcong WANG
4
;
Yunfei CHEN
5
Author Information
1. Dept.of Pharmacy，North China University of Science and Technology Affiliated Hospital，Hebei Tangshan 063000，China
2. Dept. of Clinical Nutrition，North China University of Science and Technology Affiliated Hospital，Hebei Tangshan 063000，China
3. Dept. of Respiratory Medicine，North China University of Science and Technology Affiliated Hospital，Hebei Tangshan 063000，China
4. Dept. of Pharmacy，the Second Affiliated Hospital of Hebei North University，Hebei Zhangjiakou 075000，China
5. Dept. of Clinical Nutrition，the Second Affiliated Hospital of Hebei North University，Hebei Zhangjiakou 075000，China
- Publication Type:Journal Article
- Keywords:
Shenling baizhu powder;
elderly;
sarcopenia;
nutrition support;
exercise intervention;
cost-effectiveness analysis
- From:
China Pharmacy
2024;35(21):2652-2657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the safety， effectiveness， and cost-effectiveness of elderly patients with sarcopenia receiving Shenling baizhu powder combined with nutrition and exercise intervention， providing a reference for rational clinical drug use. METHODS A total of 237 elderly sarcopenia patients were randomly assigned to an observation group （118 cases） and a control group （119 cases）. Both groups of patients received nutrition and exercise intervention； the observation group added Shenling baizhu powder （6 g each time， three times daily） on this basis. The safety， effectiveness， and cost-effectiveness of the two plans were compared after 3 months. RESULTS Both groups of patients completed the follow-up. Before intervention， no significant difference was observed in skeletal muscle index （SMI）， grip strength， and 6-minute walk test （6MWT） speed between the two groups （P＞0.05）. After intervention， the grip strength of the patients in the observation group was significantly greater than that of the control group （25.05 kg vs. 23.18 kg， P＜0.01）； the treatment response rate of sarcopenia， SMI， and 6MWT speed were higher than those of the control group， butthe differences were not statistically significant （P＞0.05）. The adverse reaction/event rate of the patients in the observation group was lower than that of the control group （14.41% vs. 16.81%， P＝0.611）， but the difference was not statistically significant. Compared with the control group’s plan， the cost of the observation group’s plan was higher （981.25 yuan vs. 913.94 yuan）， and the effect was better （effectiveness rate： 0.618 6 vs. 0.563 0）， with an incremental cost-effectiveness ratio of 1 210.61 yuan. The results of the sensitivity analysis were consistent with the cost-effectiveness analysis results. CONCLUSION Elderly patients with sarcopenia who receive Shenling baizhu powder combined with nutrition and exercise intervention can significantly strengthen grip strength without increasing the incidence of adverse reactions/events. Compared with the control group plan， the observation group needs to spend an additional 1 210.61 yuan for each additional effective patient with sarcopenia.
