Clinical application effect of ECMO in lung transplantation for recipients with combined pulmonary fibrosis and emphysema
10.3969/j.issn.1674-7445.2024130
- VernacularTitle:ECMO在肺纤维化合并肺气肿受者肺移植术中的临床应用效果
- Author:
Jialong LIANG
1
;
Jintao ZHOU
1
;
Jingyu CHEN
1
;
Yuan CHEN
1
;
Shugao YE
1
Author Information
1. Wuxi Medical Center, Nanjing Medical University, Wuxi People's Hospital, Lung Transplant Center, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
- Publication Type:OriginalArticle
- Keywords:
Lung transplantation;
Idiopathic pulmonary fibrosis;
Pulmonary emphysema;
Extracorporeal membrane oxygenation;
Vein;
Artery;
Pulmonary artery hypertension;
Complication
- From:
Organ Transplantation
2024;15(6):935-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different extracorporeal membrane oxygenation (ECMO) bypass modes on the prognosis of patients with combined pulmonary fibrosis and emphysema (CPFE) during lung transplantation. Methods A retrospective analysis was conducted on 44 CPFE patients who underwent lung transplantation, and they were divided into the venous-venous ECMO (VV-ECMO) group (30 cases) and the venous-arterial ECMO (VA-ECMO) group (14 cases). The preoperative, intraoperative, postoperative and follow-up related indicators of two groups were compared. Results Compared with the VV-ECMO group, the patients in the VA-ECMO group were younger, had higher pulmonary artery pressure before surgery, fewer posterolateral incision types, longer operation times, and higher incidence of postoperative bronchopleural fistula (all P<0.05). The pulmonary artery pressure decreased after surgery in both groups, with a greater decrease in the VA-ECMO group (P<0.05). There was no statistically significant difference in postoperative survival rates between the two groups (P>0.05). Conclusions Both VA-ECMO and VV-ECMO are safe and effective in lung transplant patients with CPFE. The bypass mode has no significant impact on the short and medium-term prognosis of the patients. VA-ECMO is more suitable for patients with higher preoperative pulmonary artery pressure.
