X-box binding protein 1 and kidney transplant-related injury
10.3969/j.issn.1674-7445.2024104
- VernacularTitle:X盒结合蛋白1与肾移植相关损伤
- Author:
Haiqiang NI
1
;
Nianqiao GONG
Author Information
1. 430030 武汉,华中科技大学同济医学院附属同济医院器官移植研究所器官移植教育部重点实验室国家卫生健康委员会器官移植重点实验室中国医学科学院器官移植重点实验室
- Keywords:
X-box binding protein 1;
Kidney transplantation;
Ischemia-reperfusion injury;
Rejection;
Endoplasmic reticulum stress;
Inositol-requiring enzyme 1α;
Renal parenchymal cell;
Immune cell
- From:
Organ Transplantation
2024;15(6):876-882
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury(IRI)and rejection are the main factors affecting the long-term survival of transplant kidneys.IRI or rejection reactions can cause endoplasmic reticulum stress(ERS)leading to renal injury.X-box binding protein 1(XBP1),as the main ERS-related protein regulating cell homeostasis,generates spliced XBP1 after splicing introns by inositol-requiring enzyme 1α(IRE1α),thereby affecting the expression of target genes and reshaping the cell environment.Appropriate ERS can promote cell survival.However,when the threshold is exceeded,excessive expression of XBP1 can lead to cell instability or death,thereby causing an imbalance in the renal internal environment,which is related to the pathogenesis and progression of kidney transplant-related injury.Therefore,the effective activation of XBP1 has a protective effect on stress injury and helps maintain the vitality and integrity of the renal system.This article reviews the ERS pathway IRE1α-XBP1,the role of XBP1 in renal parenchymal cells and immune cells,the role of XBP1 in renal ischemic injury and rejection,and the clinical detection and potential therapies targeting XBP1.It explores the potential value of targeting XBP1 in kidney transplant-related injury,aiming to provide new targets and directions for improving the prognosis of kidney transplantation.
