Advances and Challenges in the Research of Integration Methods of Animal Experimental Evidence
- VernacularTitle:动物实验证据整合方法研究的进展与挑战
- Author:
Qingyong ZHENG
1
;
Tengfei LI
2
;
Jianguo XU
1
;
Yongjia ZHOU
2
;
Zhichao MA
3
;
Na WANG
4
;
Molan LI
4
;
Wenjing YANG
4
;
Peirun WU
3
;
Haidong WANG
5
;
Jinhui TIAN
1
Author Information
1. Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou730000, China
2. School of Nursing, Gansu University of Chinese Medicine, Lanzhou730000, China
3. The Second Clinical Medical College of Lanzhou University, Lanzhou730000, China
4. The First Clinical School of Medicine, Lanzhou University, Lanzhou730000, China
5. Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou730050, China
- Publication Type:Journal Article
- Keywords:
Animal experiments;
Evidence integration;
Research progress;
Evidence-based medicine
- From:
Laboratory Animal and Comparative Medicine
2024;44(5):567-576
- CountryChina
- Language:Chinese
-
Abstract:
Integrating evidence from animal experiments is a critical component of biomedical research, providing essential prior information for in-depth investigations of disease mechanisms and new drug development. Animal models have played an irreplaceable role in simulating human diseases. However, the integration of evidence from animal experiments has faced numerous challenges, including insufficient emphasis, significant heterogeneity in study designs, high publication bias, and discrepancies with clinical research practices. This paper first identifies existing issues in the original research evidence from animal experiments, such as the selection and applicability of animal models, considerations in the design of experimental studies, and factors influencing the translation of animal experimental evidence. It then discusses various methods for integrating this evidence, including systematic review and meta-analysis, overview of systematic review/umbrella review, scoping review, and evidence mapping, while highlighting recent advancements in their application. Finally, the paper addresses the main challenges currently encountered in the integration of evidence from animal experiments and proposes targeted improvement strategies aimed at enhancing the efficiency of translating research outcomes into clinical practice and promoting the advancement of evidence-based medicine. By continuously optimizing original experimental research protocols and evidence integration practices, this work aims to establish a more efficient and scientific environment for the synthesis of evidence from animal experiments, ultimately contributing to clinical trials and human health.
