Mechanisms of Outdoor Air Pollution Affecting Cardiovascular Diseases： A Review
10.13422/j.cnki.syfjx.20241209
- VernacularTitle:室外空气污染影响心血管疾病的机制研究进展
- Author:
Chengcheng LIU
1
;
Yu LI
1
;
Yan LIANG
1
;
Shuiqing QU
1
;
Yue DAI
1
;
Tuo LIU
1
;
Lina CHEN
1
;
Luqi WANG
1
;
Yujie LI
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
air pollution;
cardiovascular disease;
epidemiology;
traditional Chinese medicine prevention and treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(23):318-326
- CountryChina
- Language:Chinese
-
Abstract:
The impact of air pollution on human health has always been a research hotspot in the global health field. Outdoor air pollutants composed of multiple components can enter the human body through various pathways. Cardiovascular diseases are a group of diseases caused by outdoor air pollutants. Studies have shown that the incidence of cardiovascular diseases， including hypertension， arrhythmia， and heart failure， is significantly increased among people exposed to air pollution environments. Air pollutants such as fine particulate matter， nitrogen dioxide， ozone， carbon monoxide， and sulfur dioxide are closely related to the occurrence of cardiovascular diseases， and short-term and long-term exposure causes different cardiovascular risks. By reviewing the relevant research reports from 2019 to 2024， this article summarizes the epidemiological evidence of cardiovascular diseases caused by different air pollutants. It generalizes the pathways through which air pollutants accelerate the progression of cardiovascular diseases. These pathways include oxidative stress， inflammatory response， thrombosis， extracellular vesicle release， endoplasmic reticulum stress， apoptosis， endothelial dysfunction， autonomic nervous system imbalance， and their interactions. Based on the different mechanisms of air pollution on cardiovascular diseases， the article analyzes the main progress in drug intervention and summarizes the roles of various active ingredients and compound prescriptions of traditional Chinese medicine in treating air pollution-related cardiovascular diseases， providing reference for the research on the mechanisms and drug interventions of air pollution-related cardiovascular diseases.
