Behavioral Assessment and Drug Treatment of Apathy in Dementia in Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20241419
- VernacularTitle:中医呆病淡漠行为评价及药物干预研究进展
- Author:
Lijinchuan DONG
1
;
Qing YANG
1
;
Xiaoxin ZHU
1
;
Qi LI
1
;
Bo PENG
1
;
Hongmei LI
1
;
Weiyan CAI
1
;
Ying CHEN
1
Author Information
1. Institute of Chinese Materia Medica， China Academy of Chinese Medical Sciences， Beijing 100700， China
- Publication Type:Journal Article
- Keywords:
apathy;
dementia;
animal models;
behavioral assessment;
drug interventions
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(23):308-317
- CountryChina
- Language:Chinese
-
Abstract:
Dementia in traditional Chinese medicine （TCM） mainly presents amnesia and dullness. Alzheimer's disease and vascular dementia belong to the category of dementia in TCM. These progressive neurological diseases have a complex etiology and a long course， and the drugs that can reverse the disease course remain to be developed. Therefore， early intervention plays a vital role in delaying the disease progression. Apathy refers to a lack of motivation that leads to the attenuation or disappearance of goal-directed behaviors， cognitive functions， and emotional responses. Clinical studies have suggested that apathy exists in the early stage of a variety of neurodegenerative diseases， being one of the key symptoms to the early diagnosis of dementia. The severity of apathy is related to the severity of dementia. Therefore， early diagnosis and treatment of apathy are of great significance to the prevention and treatment of dementia. The preclinical research on apathy in dementia is still in its infancy， and the systematic evaluation method has not been prescribed. The clinical diagnosis and treatment are also in the exploratory stage， and the complex pathophysiological mechanisms of apathy and dementia development have not been fully elucidated. This article reviews the research progress of apathy in dementia， the apathetic behaviors of dementia animal models， the behaviors of patients with apathy， and the treatment methods in recent years and summarizes the research status of apathy in dementia. This review aims to provide a theoretical basis for exploring the behavior of apathy in dementia and conducting preclinical research and evaluation of the pathogenesis and to lay a foundation for the treatment of apathy in dementia.
