Effect of Artemisinin and Its Derivatives in Treatment of Nervous System Diseases： A Review
10.13422/j.cnki.syfjx.20241205
- VernacularTitle:青蒿素及其衍生物对神经系统疾病的保护作用研究进展
- Author:
Yan LIANG
1
;
Shuiqing QU
1
;
Yu LI
1
;
Yue DAI
1
;
Chengcheng LIU
1
;
Luqi WANG
1
;
Lina CHEN
1
;
Tuo LIU
1
;
Yujie LI
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
artemisinin;
artemisinin and its derivatives;
nervous system diseases;
neuroprotection;
pharmacology of Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(23):292-299
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid development of social economy， the number of patients with nervous system diseases has increased， and the incidence of the population has a trend of younger， which has a serious impact on life health and social economy. Artemisinin is an active antimalarial component extracted and isolated from Artemisia annua， a Chinese medicinal material. Artemisinin and its derivatives， in addition to the antimalarial effect， also have anti-parasitic， anti-fungal， anti-viral， hypoglycemic， hypolipidemic， anti-tumor， and anti-inflammatory effects， showing a wide range of pharmacological activities. In the past five years， research on the new pharmacological effects of artemisinin and its derivatives has been deepening， and the efficacy of artemisinin and its derivatives in nervous system diseases has attracted much attention， including anti-neuroinflammation， anti-oxidative stress， maintaining the stability of the blood-brain barrier， regulating the release of neurotransmitters， repairing neuronal damage， and promoting neuronal regeneration. These pharmacological effects indicate that artemisinin and its derivatives are potentially capable of neuroprotection. By sorting out literature on the pharmacological activity of artemisinin and its derivatives in nervous system during 2019－2024， this paper systematically summarized the protective effects of artemisinin and its derivatives against nervous system diseases such as stroke， neurodegenerative diseases， neuroimmunological diseases， neuralgia， and nervous system tumors. This review is expected to provide clues and evidence for new indication expansion of artemisinin drugs， innovative drug development， and clinical treatment of nervous system diseases.
