Mechanism of Treatment of Hepatocellular Carcinoma with Traditional Chinese Medicine Based on Epigenetic Regulation： A Review
10.13422/j.cnki.syfjx.20250391
- VernacularTitle:中医药基于表观遗传调控肝细胞癌的作用机制研究进展
- Author:
Xianyu XU
1
;
Yongping ZHU
2
;
Yanqing LIU
2
;
Liwei GU
2
;
Junzhe ZHANG
2
;
Shengnan SHEN
2
;
Jigang WANG
1
Author Information
1. Center for Drug Research and Development，Guangdong Provincial Key Laboratory of Advanced Drug Delivery System，Guangdong Pharmaceutical University，Guangzhou 510006，China
2. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences， State Key Laboratory for Quality Ensurange and Sustainable Use of Dao-di Herbs，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
epigenetic;
hepatocellular carcinoma;
mechanism;
traditional Chinese medicine;
DNA methylation;
histone modification;
non-coding RNAs
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(23):281-291
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma （HCC） is the sixth most common cancer in the world. In recent years， the clinical early diagnosis and treatment protocols of HCC have been improved， whereas the prognosis of patients is still not satisfactory， which is due to the fact that the mechanism of HCC development has not been fully elucidated. Therefore， it is of great significance to explore the molecular mechanisms and key regulatory links of hepatocellular carcinoma development to further improve the diagnosis and treatment of HCC in China. Epigenetics has become a research hotspot because of its reversibility and easy regulation. According to relevant studies， HCC involves the accumulation of multiple genetic and epigenetic changes during the initiation， promotion， and progression stages. HCC is categorized as infantile malnutrition with accumulation， hypochondriac pain， tympan ites， and abdominal mass in traditional Chinese medicine （TCM）. In the treatment of HCC， TCM with low toxicity， multi-targets， and multi-mechanisms can inhibit tumor growth， alleviate the clinical symptoms， and enhance the quality of life of the patients. Chinese medicines and their active ingredients exert anti-HCC effects through epigenetic regulation of DNA methylation， histone modification， and non-coding RNA. Abnormal gene expression due to epigenetic regulation disorders is involved in all stages of HCC development. There are few studies on epigenetic regulation in TCM treatment of HCC， and there is still much room for development in basic and clinical trials. This paper reviews the mechanism of epigenetic regulation in HCC and summarizes the experimental results of TCM research on the related mechanism， with a view to providing a theoretical basis for future research on the mechanism of HCC development and clinical diagnosis and treatment of hepatocellular carcinoma with TCM.
