Immunomodulatory Effect of Shufeng Jiedu Capsules and Active Components in Treating Respiratory Tract Infections： A Review
10.13422/j.cnki.syfjx.20241301
- VernacularTitle:疏风解毒胶囊及有效成分在呼吸道感染中的免疫调节作用研究进展
- Author:
Xinying LI
1
;
Lei BAO
1
;
Jing SUN
1
;
Shuran LI
1
;
Ronghua ZHAO
1
;
Yanyan BAO
1
;
Xiaolan CUI
1
;
Shanshan GUO
1
;
Zihan GENG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences， Beijing 100700，China
- Publication Type:Review
- Keywords:
respiratory tract infections;
pneumonia;
Shufeng Jiedu capsules;
immunomodulation;
reaserch progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(23):261-268
- CountryChina
- Language:Chinese
-
Abstract:
Shufeng Jiedu capsules， a Chinese patent medicine composed of Polygoni Cuspidati Rhizoma et Radix， Forsythiae Fructus， etc.， has shown positive effects in the clinical treatment of upper respiratory tract infections， pharyngitis， acute exacerbation of chronic obstructive pulmonary disease （AECOPD）， and coronavirus disease 2019 （COVID-19）. The available evidence suggests that Shufeng Jiedu capsules can modulate the proportions of immune cells and the concentrations of inflammatory cytokines， thereby easing symptoms and enhancing cure rates. The existing reviews predominantly focus on the clinical applications of Shufeng Jiedu capsules， while the comprehensive review of the immunomodulatory effect of this medicine remains to be carried out. This review delineates the immune responses triggered by respiratory tract infections， and then summarizes the clinical application of Shufeng Jiedu capsules and its main chemical components. Principally， this review summarizes the immunomodulatory and anti-inflammatory mechanisms， mainly focusing on various immune cells including macrophages， neutrophils， natural killer （NK） cells， and lymphocytes. In addition， this paper discusses the influences of Shufeng Jiedu capsules and its main chemical components on signaling pathways， secretion of pro-inflammatory cytokines， and antibody production. In terms of innate immunity， the intervention effects of Shufeng Jiedu capsules are highlighted by its capacity to inhibit the activation of nuclear factor kappa-B （NF-κB） and interferon regulatory factor 3 （IRF3） pathways. Additionally， Shufeng Jiedu capsules have been shown to reduce the expression of microtubule-associated protein 1 light chain 3 Ⅱ （LC3Ⅱ）， thereby suppressing the inflammation and autophagy of macrophages. Furthermore， the influence of this medicine extends to altering the proportions of neutrophils and nature killer（NK） cells. Regarding adaptive immunity， Shufeng Jiedu capsules can increase the proportion of T cells in peripheral blood and restore the balance of B cells. This review aims to provide directions for the further research and clinical application of Shufeng Jiedu capsules.
