Research advances in microsomal prostaglandin E2 synthase-1 targeted anti-inflammatory drugs
10.11665/j.issn.1000-5048.2023032001
- VernacularTitle:靶向微粒体前列腺素E2合酶-1的抗炎药物研究进展
- Author:
Shuang JI
1
;
Lihong CHEN
Author Information
1. 大连医科大学医学科学研究院,大连 116044
- Keywords:
non-steroidal anti-inflammatory drugs;
prostaglandin E2;
mPGES-1;
inflammatory diseases
- From:
Journal of China Pharmaceutical University
2024;55(5):697-707
- CountryChina
- Language:Chinese
-
Abstract:
Microsomal prostaglandin E2 synthase 1(mPGES-1),the main terminal synthase of prostaglandin E2(PGE2),plays a crucial role in inflammatory diseases.Compared to non-steroidal anti-inflammatory drugs(NSAIDs),mPGES-1 inhibitors are promising agents for their better specificity and higher safety.This article summarizes the research status of mPGES-1 in inflammation and cardiovascular diseases,systematically reviews the research progress of the development of mPGES-1 inhibitors,elaborates on their therapeutic effects in different inflammation animal models and inflammatory diseases,and discusses the possible existing challenges,aiming to provide some guidance and reference for the subsequent research of anti-inflammatory drugs.
