Research advances in microsomal prostaglandin E2 synthase-1 targeted anti-inflammatory drugs
10.11665/j.issn.1000-5048.2023032001
- VernacularTitle:靶向微粒体前列腺素E2合酶-1的抗炎药物研究进展
- Author:
Shuang JI
1
;
Lihong CHEN
Author Information
1. 大连医科大学机构
- Publication Type:Journal Article
- Keywords:
non-steroidal anti-inflammatory drugs / prostaglandin E2 / mPGES-1 / inflammatory diseases
- From:
Journal of China Pharmaceutical University
2024;55(5):697-707
- CountryChina
- Language:Chinese
-
Abstract:
Microsomal prostaglandin E2 synthase 1 (mPGES-1), the main terminal synthase of prostaglandin E2 (PGE2), plays a crucial role in inflammatory diseases. Compared to non-steroidal anti-inflammatory drugs (NSAIDs), mPGES-1 inhibitors are promising agents for their better specificity and higher safety. This article summarizes the research status of mPGES-1 in inflammation and cardiovascular diseases, systematically reviews the research progress of the development of mPGES-1 inhibitors, elaborates on their therapeutic effects in different inflammation animal models and inflammatory diseases, and discusses the possible existing challenges, aiming to provide some guidance and reference for the subsequent research of anti-inflammatory drugs.
