Drug delivery systems for sensitization of glioblastoma radiotherapy

VernacularTitle:药物递送系统介导的脑胶质瘤放疗增敏
Author: Mingxuan LIU ¹ ; Yun GUO ; Tao SUN
Author Information

1. 复旦大学药学院智能化递药教育部重点实验室
Publication Type:Journal Article
Keywords: glioblastoma / drug delivery system / radiation tolerance / sensitization of radiotherapy / tumor microenvironment
From: Journal of China Pharmaceutical University 2024;55(5):624-633
CountryChina
Language:Chinese
Abstract: Glioblastoma is a common malignant tumor in the central nervous system, often exhibiting radiation resistance. Drug delivery systems can help to overcome the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma, thereby enhancing the efficacy of radiation therapy, which has received increasing attention. This review focuses on the relationship between radiation resistance and the intrinsic DNA damage repair mechanism, the clearance of reactive oxygen species with DNA and membrane attack, and the rapid proliferation of glioblastoma stem cells. It also discusses the performance of inorganic nanomaterials, organic composite materials, and bionic drug delivery systems in solving the problem of trans-barrier delivery, and summarizes the design method of drug delivery systems for crossing the blood-brain barrier and targeted delivery of radiation sensitizers to glioblastoma, to provide some possible direction for solving the clinical translation problems of nano delivery systems.