Research advances in modulating microglia for intervening in Alzheimer’s disease
- VernacularTitle:调控小胶质细胞干预阿尔茨海默病的研究进展
- Author:
Yuan CHANG
1
;
Mageta Samwel MAGETA
;
Nibowen LI
;
Yingqi TANG
;
Huangjuan LI
;
Chenggen QIAN
Author Information
1. 中国药科大学药学院药剂系
- Publication Type:Journal Article
- Keywords:
microglia / Alzheimer’s disease / Aβ / tau / neuroprotection
- From:
Journal of China Pharmaceutical University
2024;55(5):603-612
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world with dementia as its main manifestation. The pathological regulation strategies based on microglia in immune cells have shown their unique advantages in treating AD by preventing the pathological progression of AD at an early stage. This paper firstly introduces the role of microglia in the pathogenesis of AD, then summarizes the relationship between microglia and the common key pathologies of Aβ, tau proteins, neuroinflammation, and impaired energy metabolism in AD, and finally reviews feasible microglia-targeted intervention strategies against AD with some discussion about some current issues for improvement in each study, in the hope of deepening the understanding of strategies that regulate microglia to block AD pathology and providing some new ideas for the early intervention and treatment of AD patients in the future.
