COVID-19 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2. Although not well established, COVID-19 infection carries a great effect on pregnant patients with increased severity compared to the nonpregnant population. Cytokine storm is a severe immune reaction and is one of the pathogeneses of COVID-19 infection. Studies have shown the benefit of hemoperfusion in managing cytokine storm, but the use in the pregnant population remains limited. We report the case of a 41-year-old pregnant woman at 25 weeks and 5 days age of gestation infected with COVID-19 presenting with difficulty of breathing and desaturation and then underwent hemoperfusion which improved her clinical condition.