Arrhythmia induced by clozapine in patients with schizophrenia： a Meta-analysis
10.11886/scjsws20231211002
- VernacularTitle:氯氮平致精神分裂症患者心律失常的Meta分析
- Author:
Yadi CHEN
1
;
Yu DING
1
;
Qianqian LI
1
;
Xiaolei LIU
2
;
Weiwei WANG
1
Author Information
1. The Second Affiliated Hospital of Kunming Medical University， Kunming 650033， China
2. The First Affiliated Hospital of Kunming Medical University， Kunming 650032， China
- Publication Type:Review
- Keywords:
Clozapine;
Schizophrenia;
Arrhythmias;
Meta-analysis
- From:
Sichuan Mental Health
2024;37(5):475-481
- CountryChina
- Language:Chinese
-
Abstract:
BackgroundClozapine belongs to atypical antipsychotic drugs that has shown significant efficacy in treating schizophrenia. However， clozapine can induce arrhythmias in patients. Currently， there is a lack of systematic research on the types and incidence of clozapine-induced arrhythmias. ObjectiveTo explore the types and incidence of arrhythmias in patients with schizophrenia induced by clozapine through Meta-analysis， so as to provide references for clinical treatment. MethodsOn October 31， 2022， a search was conducted through PubMed， Embase， Cochrane Library and China National Knowledge Infrastructure （CNKI） to collect relevant literature on clozapine-induced arrhythmia in patients with schizophrenia. Joanna Briggs Institute （JBI） was used to evaluate the quality of the included literature. Meta-analysis was conducted using Review Manager 5.4. ResultsA total of 12 studies were included， involving 42 490 schizophrenia patients taking clozapine. The incidence of arrhythmias caused by clozapine was 23% （95% CI： 0.16~0.29）. Among them， the incidence of tachycardia was 25% （95% CI： 0.15~0.35）， atrial arrhythmia was 6% （95% CI： -0.02~0.14）， ventricular arrhythmia was 7% （95% CI： -0.02~0.16）， conduction block was 2% （95% CI： 0~0.04）， QTc prolongation was 4% （95% CI： -0.04~0.12） and T-wave changes was 23% （95% CI： 0.16~0.30）. ConclusionSchizophrenia patients taking clozapine may increase their risk of developing arrhythmia， with tachycardia being the most prevalent. ［Funded by Graduate Innovation Fund of Kunming Medical University （number， 2023S302）］
