Histomorphometric evaluation of bone healing with natural calcium carbonatederived bone substitutes in rat calvarial defect.
10.5051/jkape.2008.38.1.83
- Author:
Chung Ho LEE
1
;
Je Hee JANG
;
Jae Mok LEE
;
Jo Young SUH
;
Jin Woo PARK
Author Information
1. Department of Periodontology, School of Dentistry, Kyungpook National University, Korea. jinwoo@knu.ac.kr
- Publication Type:Original Article
- Keywords:
bone substitute;
calcium carbonate;
osteoconductivity;
histomorphometry
- MeSH:
Animals;
Bone Substitutes;
Calcium;
Calcium Carbonate;
Durapatite;
Minerals;
Osteogenesis;
Rats;
Skull;
Transplants
- From:The Journal of the Korean Academy of Periodontology
2008;38(1):83-90
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study investigated the osteoconductivity of natural calcium carbonate-derived bone substitutes, hen eggshell (ES), and compared with those of commercial bone substitutes. MATERIALS AND METHODS: Osseous defects created in the rat calvaria were filled with particulated ES(ES-1), ES with calcium-deficient hydroxyapatite surface layer (ES-2), Biocoral(Inoteb, France), and Bio-Oss(Geistlich Pharma, Wolhusen, Switzerland). After 4 and 8 weeks of healing, histomorphometic analysis was performed to evaluate the amount of newly formed mineralized bone area (NB%). RESULTS: Histologic and histomorphometric analysis showed new bone formation and direct bony contact with the grafted materials in all groups. At 4 weeks, Biocoral group showed greater NB% compared to Bio-Oss and ES-1 groups (P<0.05). At 8 weeks, Biocoral and ES-2 groups showed significantly greater NB% compared to Bio-Oss group (P<0.05). CONCLUSION: These results indicate that natural calcium carbonate-derived bone substitutes with microporous calciumdeficient hydroxyapatite surface layer may be an effective materials treating osseous defects.
