Research progress of lipid metabolism in the pathogenesis of age-related macular degeneration
10.12025/j.issn.1008-6358.2024.20240024
- VernacularTitle:脂质代谢在年龄相关性黄斑变性发病机制中的研究进展
- Author:
Yu SHANG
1
;
Rong ZOU
1
;
Yuanzhi YUAN
1
Author Information
1. Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
- Publication Type:Review
- Keywords:
age-related macular degeneration;
lipid metabolism;
lipoprotein
- From:
Chinese Journal of Clinical Medicine
2024;31(5):819-825
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is the first permanent cause of vision loss in developed countries, which is also a disease with high incidence and blindness rate in China. Studies have demonstrated that lipid metabolism is one of the key mechanisms of AMD. However, the precise mechanism remains unclear and medications for AMD treatments based on this mechanism have not yet been established. In this review, we critically review relevant studies to examine the associations between lipid metabolism and AMD from the perspectives of lipoproteins, lipid metabolism-related molecular, and lipid metabolism-related treatments, aiming to help understand the roles that lipid metabolism mechanisms play in the development and progression of AMD and to provide ideas for future targeted lipid metabolism therapies.
