Predictive value of 3D quantitative shape features based on CT for disease-free survival of primary gastrointestinal stromal tumors
10.12025/j.issn.1008-6358.2024.20240850
- VernacularTitle:基于CT的3D定量形状特征对原发性胃肠道间质瘤术后无病生存期的预测价值
- Author:
Xiaoshan CHEN
1
,
2
;
Jiejun CHEN
1
,
2
;
Yutao YANG
3
;
Jianjun ZHOU
1
,
4
;
Shengxiang RAO
1
,
2
Author Information
1. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China
2. Shanghai Institute of Medical Imaging, Shanghai 200032, China.
3. Department of Radiology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
4. Department of Radiology, Zhongshan Hospital (Xiamen Branch), Fudan University, Xiamen 361015, Fujian, China.
- Publication Type:Shortarticle
- Keywords:
gastrointestinal stromal tumors;
computed tomography;
disease-free survival;
maximum 3D diameter;
spherical disproportion
- From:
Chinese Journal of Clinical Medicine
2024;31(5):804-810
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the predictive value of 3D quantitative shape features based on enhanced CT for disease-free survival (DFS) of primary gastric gastrointestinal stromal tumors (GIST) patients receiving curative resection. Methods From January 2010 to December 2016, a total of 154 patients with primary gastric GIST who received curative resection in Zhongshan Hospital, Fudan University were retrospectively collected. The conventional CT imaging features and 3D quantitative shape features of tumors were evaluated, and the influencing factors of DFS were analyzed by univariate and multivariate Cox regression. Cut-off values were extracted, and Kaplan-Meier curves were used for survival analysis. Results Maximum 3D diameter (HR=1.829, 95%CI 1.389-2.408, P＜0.001) and spherical disproportion (HR=2.153, 95%CI 1.474-3.146, P＜0.001) were independent risk factors for DFS in primary gastric GIST. Kaplan-Meier curves showed that patients with maximum 3D diameter＞90.5 mm and spherical disproportion＞1.5 showed shorter DFS after curative resection (P＜0.001). Conclusion Maximum 3D diameter and spherical disproportion based on preoperative enhanced CT are valuable in the diagnosis of postoperative DFS in primary gastric GIST.
