Efficacy evaluation of comprehensive treatment for chronic dacryocystitis with meibomian gland dysfunction
10.3980/j.issn.1672-5123.2024.11.27
- VernacularTitle:慢性泪囊炎合并睑板腺功能障碍综合治疗后疗效评价
- Author:
Yi ZHANG
1
,
2
,
3
,
4
,
5
;
Xiaozhao YANG
1
,
2
,
3
,
4
,
5
;
Hua YANG
1
,
2
,
3
,
4
,
5
;
Xuan ZHENG
1
,
2
,
3
,
4
,
5
;
Haiqing LU
1
,
2
,
3
,
4
,
5
;
Chao LIU
1
,
2
,
3
,
4
,
5
Author Information
1. Department of Ophthalmology,Xi'an No.1 Hospital
2. Shaanxi Institute of Ophthalmology
3. Shaanxi Key Laboratory of Ophthalmology
4. Clinical Research Center for Ophthalmology Diseases of Shaanxi Province
5. Department of Ophthalmology, First Affiliated Hospital of Northwest University, Xi'an 710002, Shaanxi Province, China
- Publication Type:Journal Article
- Keywords:
chronic dacryocystitis;
meibomian gland dysfunction;
ocular surface microenvironment;
lacrimal apparatus disease
- From:
International Eye Science
2024;24(11):1836-1841
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the efficacy of lacrimal duct laser dacryoplasty combined with intubation and postoperative meibomian gland treatment in patients with chronic dacryocystitis complicated by meibomian gland dysfunction.METHODS: Data were collected from 128 patients with chronic dacryocystitis complicated by meibomian gland dysfunction treated at Xi'an No.1 Hospital from March 2021 to December 2022. All patients underwent lacrimal duct laser dacryoplasty combined with intubation. Postoperatively, those patients were randomly divided into two groups: group A(64 cases, without meibomian gland treatment)and group B(64 cases, with meibomian gland treatment). The lacrimal intubation was removed at 3 mo after surgery to evaluate the patency rate of lacrimal irrigation. Additionally, changes in the ocular surface disease index(OSDI)score, non-invasive tear film break-up time, tear meniscus height, conjunctival hyperemia analysis, meibomian gland analysis, tear lipid layer thickness, tear ferning test, and conjunctival impression cytology were compared between the two groups.RESULTS: The lacrimal irrigation patency rates in the group A and group B were 78.1% and 81.2% respectively, with no statistically significant difference between the two groups(P>0.05); compared with the group A, group B showed a significant extension in non-invasive tear breakup time at 3 mo after surgery, and the OSDI score, conjunctival hyperemia analysis, tear ferning test and conjunctival impression cytology grading were all significantly decreased(all P<0.05), while there was no significant difference in tear meniscus height, tear lipid layer thickness and meibomian gland loss score between the two groups(all P>0.05).CONCLUSION: Comprehensive treatment for patients with chronic dacryocystitis combined with meibomian gland dysfunction have improved patients' comfort, tear film stability, and reduces local inflammatory response. It is important to simultaneously address ocular surface microenvironment abnormalities during surgical treatment to achieve satisfactory efficacy.
