Meta-analysis of the clinical efficacy of low-concentrations atropine in controlling adolescent myopia
10.3980/j.issn.1672-5123.2024.11.18
- VernacularTitle:低浓度阿托品控制青少年近视临床疗效的Meta分析
- Author:
Zhidong JIANG
1
;
Lian CHENG
1
;
Yong ZHANG
1
;
Lei LIANG
1
;
Jinting RUAN
1
;
Yanfei HUANG
1
;
Liangliang LI
1
Author Information
1. Department of Ophthalmology, Nanlang Branch, Zhongshan City People's Hospital, Zhongshan 528400, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
myopia;
low-concentrations atropine;
adolescents;
efficacy results;
Meta-analysis
- From:
International Eye Science
2024;24(11):1784-1794
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To systematically evaluate the efficacy and safety of low-concentrations atropine eye drops in controlling adolescent myopia.METHODS:A computer search was conducted on Wanfang Data, CNKI, VIP, PubMed, Cochrane Library, and Embase databases from January 2010 to March 2024 on clinical studies on low-concentration atropine eye drops for controlling adolescent myopia. Two researchers independently screened trials, extracted data, evaluated risk of bias and quality, and used Review Manager5.4 software to perform Meta-analysis.RESULTS:A total of 17 articles, involving 3 764 cases and 3 952 eyes, were included. The Meta-analysis showed that compared with the control group, low concentrations of atropine could effectively slow down the growth of axial length [MD=-0.15, 95% CI(-0.20, -0.10), P<0.00001], significantly controlled the changes in spherical equivalent [MD=0.39, 95% CI(0.29, 0.48), P<0.00001], and had a significant effect on pupil diameter [MD=0.80, 95% CI(0.33,1.28), P=0.0010] and amplitude of accommodation [MD=-2.54, 95%CI(-4.49, -0.60), P=0.01].CONCLUSION:Low-concentrations atropine are effective in controlling spherical equivalent and axial length of myopia in adolescents, significantly affecting pupil diameter and amplitude of accommodation, and effectively delaying the progression of myopia.
