Comprehensive Understanding of Immune Cells in The Pathogenesis of Non-alcoholic Fatty Liver Disease
10.16476/j.pibb.2024.0045
- VernacularTitle:免疫细胞在非酒精性脂肪性肝病发病机制中的作用
- Author:
Fei-Fan OUYANG
1
;
Madiha RASHEED
2
;
Bo LI
1
;
Yu-Lin DENG
2
Author Information
1. Advanced Research Institute of Multidisciplinary Science, Beijing Institute of Technology, Zhuhai 519088, China
2. Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing 100081, China
- Publication Type:Journal Article
- Keywords:
non-alcoholic fatty liver disease;
metabolically associated fatty liver disease (MAFLD);
T cells;
myeloid cells;
mesenchymal stem cells
- From:
Progress in Biochemistry and Biophysics
2024;51(9):2082-2100
- CountryChina
- Language:English
-
Abstract:
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, defined by several phases, ranging from benign fat accumulation to non-alcoholic steatohepatitis (NASH), which can lead to liver cancer and cirrhosis. Although NAFLD is a disease of disordered metabolism, it also involves several immune cell-mediated inflammatory processes, either promoting and/or suppressing hepatocyte inflammation through the secretion of pro-inflammatory and/or anti-inflammatory factors to influence the NAFLD process. However, the underlying disease mechanism and the role of immune cells in NAFLD are still under investigation, leaving many open-ended questions. In this review, we presented the recent concepts about the interplay of immune cells in the onset and pathogenesis of NAFLD. We also highlighted the specific non-immune cells exhibiting immunological properties of therapeutic significance in NAFLD. We hope that this review will help guide the development of future NAFLD therapeutics.
