Meta-analysis of effect of pre-exercise intervention on immune response to influenza vaccine
10.13200/j.cnki.cjb.004306
- VernacularTitle:预运动干预对流感疫苗免疫应答效果的Meta分析
- Author:
KONG Haijun
- Publication Type:Journal Article
- Keywords:
Pre-exercise intervention;
Influenza vaccine(InfV);
Immune response;
Meta-analysis
- From:
Chinese Journal of Biologicals
2024;37(10):1206-1213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of pre-exercise on immune response to influenza vaccine(InfV) in healthy adults by Meta-analysis, so as to provide evidence-based basis for the study of "exercise adjuvant" of InfV immune response.Methods PubMed, Cochrane Library, EMbase, Web of Science database, CNKI, Wanfang Data Knowledge Service Platform(Wanfang), and SinoMed were searched to screen the research literature of randomized controlled trials(RCTs) about the effect of pre-exercise on immune response to InfV in adults. Cochrane bias risk assessment tool was used to evaluate literature quality, and Stata 15.0 software was used for Meta-analysis.Results A total of 21 RCT studies on the effect of pre-exercise intervention on immune response to InfV were included, with 702 subjects in the experimental group and 698 subjects in the control group. There was a low probability of risk bias in the included studies. Meta-analysis showed that, compared with the control group, pre-exercise significantly increased the antibody titer and serum protection rate [OR = 1. 38(95% CI: 1. 20-1. 56), P < 0. 05] of influenza virus A H1N1 [MD = 0. 47(95% CI: 0. 36-0. 58), P < 0. 05], influenza virus A H3N2 [MD =0. 34(95% CI:0. 21-0. 47), P < 0. 05], and influenza virus B [MD = 0. 34(95% CI: 0. 22-0. 46), P < 0. 05] in adults after InfV vaccination. The results of subgroup analysis showed that chronic pre-exercise significantly increased the influenza virus antibody titer and serum protection rate [OR = 1. 42(95% CI: 1. 22-1. 62), P < 0. 05] in adults after InfV vaccination,including influenza virus A H1N1[MD = 0. 72(95% CI: 0. 54-0. 90), P < 0. 05], influenza virus A H3N2 [MD = 0. 52(95%CI: 0. 15-1. 09), P < 0. 05], and influenza virus B [MD = 0. 81(95% CI: 0. 53-1. 09), P < 0. 05]. The effect of acute preexercise on antibody titers of type A H3N2 [MD = 0. 14(95% CI: 0-0. 29), P > 0. 05] and influenza virus B [MD = 0. 22(95% CI: 0. 09-0. 36), P > 0. 05] after InfV vaccination still needs further verification. Age may be a factor limiting the titer of influenza virus antibodies in subjects receiving InfV vaccination after pre-exercise.Conclusion Pre-exercise intervention can effectively improve the immune response after InfV vaccination in adults. Follow-up high-quality studies are needed to identify exercise regimens that improve immune response to InfV.
