Role of statins in chronic liver disease
- VernacularTitle:他汀类药物在慢性肝病中的作用
- Author:
Xikun YANG
1
,
2
;
Hui LI
;
Zijian ZENG
;
Xuan WU
;
Kaixin WANG
Author Information
- Keywords: Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hepatic Fibrosis; Liver Cirrhosis; Carcinoma,Hepatocellular
- From: Journal of Clinical Hepatology 2024;40(10):2104-2108
- CountryChina
- Language:Chinese
- Abstract: Chronic liver disease is the"devil's trilogy"in which the liver progresses from inflammation and fibrosis to liver cirrhosis and hepatocellular carcinoma,which poses a great challenge for hepatologists worldwide.Statins have played a significant role in the treatment of cardiovascular diseases and hyperlipidemia since their introduction,and in recent years,they have also demonstrated the potential to improve hepatic steatosis,exert an anti-inflammatory effect,regulate the phenotype of hepatic stellate cells,reduce portal venous pressure,and improve hepatic microcirculation in chronic liver disease.This article reviews the latest advances in the basic and clinical studies of statins in chronic liver disease,in order to provide new insights into the research,prevention,and treatment of chronic liver disease.
