Research advances in the mechanism of action of nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome in autoimmune hepatitis

VernacularTitle:NLRP3炎症小体在自身免疫性肝炎中的作用机制
Author: Lifei WANG ¹ ; Longlong LUO ¹ ; Guojing XING ² ; Lixia LU ² ; Bin LI ² ; Jiucong ZHANG ² ; Xiaohui YU ²
Author Information

1. The First Clinical Medical College of Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Department of Gastroenterology， The 940 Hospital of Joint Logistic Support Force of PLA， Lanzhou 730050， China
Publication Type:Review
Keywords: Hepatitis， Autoimmune; NLR Family， Pyrin Domain-Containing 3 Protein; Therapeutics
From: Journal of Clinical Hepatology 2024;40(10):2092-2097
CountryChina
Language:Chinese
Abstract: Autoimmune hepatitis （AIH） is chronic hepatitis caused by the attack of live cells by the immune system， and at present， the pathogenesis of AIH remains unclear. Inflammasomes are important components of innate immunity and are involved in a variety of pathophysiological processes. Studies have shown that inflammatory response associated with nucleotide-binding oligomerization domain-like receptor protein 3 （NLRP3） plays an important role in the pathogenesis of AIH， which mainly mediates the release of proinflammatory factors and pyroptosis， thereby participating in the pathophysiological process of AIH. Therefore， the development and progression of AIH can be delayed by inhibiting the activation of NLRP3 inflammasomes， which provides new ideas for the prevention and treatment of AIH.